Volatile mobile phases
Use volatile buffers and additives compatible with the selected ionization mode. Avoid non-volatile salts that can contaminate the source or suppress signal.
Column and mobile-phase choices for sensitive LC–MS analysis.
Use volatile buffers and additives compatible with the selected ionization mode. Avoid non-volatile salts that can contaminate the source or suppress signal.
Narrow-bore and shorter columns can reduce solvent consumption and support faster analysis, provided extra-column volume is controlled. Match particle size to the pressure capability of the LC system.
Adequate retention helps separate analytes from matrix components that may cause ion suppression. Evaluate aqueous-compatible phases for polar compounds and C18 phases for broad reversed-phase coverage.
Optimize needle wash, strong-solvent rinse and column wash steps. Verify blank response after high-concentration samples and strongly retained matrices.
View product information, selection guidance and available configurations.
View product information, selection guidance and available configurations.
View product information, selection guidance and available configurations.
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