Manufacturer: Nomura Chemical Co., Ltd.India distributor: Akira Analytical Solutions Pvt. Ltd.

Application Note: Carotenoid Separation

Practical guidance for resolving carotenoids and geometric isomers using C30 selectivity.

This application note provides a method-development framework. Final conditions must be validated with the actual analytes, matrix, detector and laboratory system.

Why C30

Carotenoids are highly hydrophobic and may occur as closely related geometric isomers. C30 phases provide stronger shape selectivity than conventional C18 and are therefore a strong starting point for complex carotenoid profiles.

Solvent selection

Use solvent systems capable of maintaining carotenoid solubility while providing controlled selectivity. Methanol, acetonitrile and stronger non-polar modifiers may be evaluated according to sample composition and instrument compatibility.

Temperature and light control

Carotenoids can be sensitive to heat, oxygen and light. Prepare samples promptly, minimize exposure and maintain a controlled column temperature to improve retention-time and selectivity consistency.

Resolution strategy

Use a shallower gradient around critical isomer pairs, reduce flow where practical and avoid excessive injection volume. Confirm system dwell volume before transferring a gradient method.

Column selection

Recommended Develosil Starting Points

Develosil C30-UG

View product information, selection guidance and available configurations.

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